【Abstract】 Objective To study the effect of meteorological factors on rats density by Response surface methodology（RSM） based on correlation and regression analysis. Methods The meteorological factors and rats density were monitored continuously. A response surface model was made by the correlation and regression analysis of them. Results Linear regression analysis（P＜0.030）indicated that monthly average minimum temperature， sunshine time and precipitation were the main influence factors， and the multiple correlation coefficient was 0.716. However， RSM suggested that monthly average minimum temperature（P＝0.003）, precipitation square（P＝0.059）， interaction of monthly minimum temperature and sunshine（P＝0.027） affected mostly the density of rats， and its multiple correlation coefficient was 0.761. Conclusion The effect of meteorological factors on the rats density could be evaluated by RSM model.  This model was superior to linear regression model. The effect of meteorological factors on rats density was resulted from multiple factors and their interaction.

Objective To study efficacy of the mixture including pyrethroid, avermectin and tebuconazol to hygiene pest. Methods Efficacy of this mixture was evaluated with KT ₅₀ and LC ₅₀ of them to hygiene pest. Results This mixture had better efficacy than other mixtures composed of part elements to mosquito, housefly and cockroach( P<0.001). The rate of knockdown and the mortality of the mixture to Mulex pipiens pallens, Musca domestica or Blattella germanica were all 100% after treated for 1 h and 24 h, respectively. The LC ₅₀ value of it to the larvae of C.pipiens pallens and M.domestica were 0.025 μg/ml and 0.41 μg/ml, respectively. The oothecae hatchability of B.germanica and Periplaneta americana decreased to 94% and 76%, respectively. The knockdown rate of the mixture to C.pipiens pallens, M.domestica, B.germanica and P.americana were all 100% after 1 h treated in analogous site. The 24 h mortality to C.pipiens pallens, M.domestica or B.germanica was 100% and the 48 h mortality to P.americana also reached 100%. According to GB/T 17322.1, the control efficacy of the mixture achieved A degree. Conclusion This mixture had good control effect on common hygiene pest, and also provided new method for the control of agriculture pest and hygiene pest.